我科中标的国家省级课题和发表的国际论文

一、国家、省级课题

1.《基于TLR-4/Klotho通路探讨天马颗粒Ⅲ抗大肠癌的作用机制》,国家自然科学基金。

2.《中药复方止痛促愈的机制初探》，国家自然科学基金。

3.《天马颗粒Ⅲ通过RAGE/Klotho途径调控大肠癌的机制研究》，中国博士后科学基金特别资助。

4.《天马颗粒通过HMGB1/Klotho途径抑制大肠癌的研究》，中国博士后科学基金面上资助。

5.《天马颗粒调控结直肠癌细胞Klotho基因表观遗传学的研究》，湖南省2016年博士后科研人员日常经费资助。

6.《RPH+简化外切内扎术治疗混合痔的多中心临床研究》，湖南省中医药管理局科研计划基金。

7.《PPMID/P38MAPK/P53信号轴在结直肠癌发病中的作用及天马颗粒剂干预机制研究》，湖南省教育厅资助项目。

8.《基于NLRP3炎症体相关信号通路研究白芍七物颗粒调节溃疡性结肠炎免疫紊乱的机制》，国家自然科学基金。

9.《白术七物颗粒对结肠慢传输型便秘小鼠肠神经递质及Cajal间质细胞的影响》，湖南省自然科学基金。

二、发表的国际论文

1. Yu Liu，Tian-Shu Peng，Xiang-Dang Hu，Shuai-Jun Li，Yong-Heng He*， Fan Hu and Jinbo Jiang，Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration，Bangladesh Journal of Pharmacol，2016,(11):402-409

2. Hai-Yan Lu，Tian-Shu Peng，Xiang-Dang Hu，Shuai-Jun Li，Min-Luo， Yong-Heng He* and TianNie，Quercetin potentiates the effect of γδ T cells via modulating the expressions of Granzyme B，perforin and IFN-γ and also regulates the Wnt/β-catenin signalling pathway in human colon cancer cells，Bangladesh Journal of Pharmacol，2015,(10):251-259

3. TianShu Peng，YongHeng He*，Tian Nie，XiangDang Hu，Hai-Yan Lu， Jian Yi，YuFei Shuai and Min Luo，PPM1D is a prognostic marker and therapeutic target in colorectal cancer.Experimental and therapeutic medicine，2014,(8):430-434

4. Xie B, Cao K, Li J, Chen J, Tang J, Chen X, Xia K, Zhou X, Cheng Y, Zhou J, Xie H. Hmgb1 inhibits Klotho expression and malignant phenotype in melanoma cells by activating NF-κB. Oncotarget. 2016,7(49):80765-80782. IF 5.008.

5. Junkun Zhan ，Guoshun Shu，Lianwen Yuan，Jianping Zhu,Biao Xie*.Clinical Features of Fungal Peritonitis with Candida Albicans Infection after Gastric and Duodenal Perforation，Emergency Medicine: Open Access,2015,5(4):1-3.

6. Liu G, Xie B, Gong L, Zhou J, Shu G. The expression of p66Shc protein in benign, premalignant, and malignant gastrointestinal lesions. Pathol Oncol Res. 2014,20(3):733-739. IF 1.94

7. Xie B, Chen J, Liu B, Zhan J*. Klotho acts as a tumor suppressor in cancers. Pathol Oncol Res. 2013;19:611-617. IF 1.94

8. Xie B, Zhou J, Shu G, Liu DC, Zhou J, Chen J, Yuan L*. Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. Cancer Cell Int. 2013 ;13:18. IF 2.884

9. Xie B, Zhou J, Yuan L, Ren F, Liu DC, Li Q, Shu G*. Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma. Hum Pathol. 2013;44:795-801. IF 2.791

10. Shu G, Xie B, Ren F, Liu DC, Zhou J, Li Q, Chen J, Yuan L, Zhou J*. Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells. Cell Oncol (Dordr). 2013;36:121-129. IF3.562